First Demonstration of SARM1 MOA: Advancing Therapeutic Discovery through XtalPi’s AI-Enhanced Cryo-EM Platform
XtalPi’s AI-powered Cryo-EM platform tackled the difficulties of elucidating SARM1, known for its complex conformational heterogeneity and data demands. Our platform provided high-resolution insights into inhibitor binding, advancing rational drug design and target validation.
Our Key Results:
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First demonstration of SARM1’s mechanism of action (MOA) with a non-covalent small molecule inhibitor-ADPR generated by a SARM1-catalyzed base-exchange reaction.
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Doubled efficiency in particle image processing.
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Achieved 2.8 Å resolution of the SARM1-Inhibitor complex.